Publications
Journal
(Under Review)
HMOX-1 positive omental macrophages as a therapeutic target in ovarian high grade serous carcinoma
Sarah Spear, Olivia Le Saux, Hasan B. Mirza, Katie Tyson, Jasmine Bickel, Fabio Grundland-Freile, Alexandros Siskos, Cristina Balcells Nadal, Josephine B. Walton, Chloé Woodman, Darren P. Ennis, Nayana Iyer, Carmen Aguirre Hernandez, Yuewei Xu, Pavlina Spiliopoulou, James D Brenton, Ana Costa-Pereira, Hector C. Keun, Evangelos Triantafyllou, James Arnold and Iain A. McNeish
(Accepted)
Nature Communications
The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma: the BriTROC-1 study
P-S. Smith, T. Bradley, L. Morrill Gavarró, T. Goranova, D. P. Ennis, H. Mirza, D. De Silva, A.M.
Piskorz, S. Al-Khalidi, C. Sauer, I-G. Funingana, M.A.V. Reinius, G. Giannone, L-A. Lewsley, J. Stobo, J.
McQueen, G. Bryson, M. Eldridge, The BriTROC Investigators, G. Macintyre, F. Markowetz, J.D.
Brenton, I.A. McNeish
June 2023
JAMA Oncology
Efficacy and Safety of Weekly Paclitaxel Plus Vistusertib vs Paclitaxel Alone in Patients With Platinum-Resistant Ovarian High-Grade Serous Carcinoma: The OCTOPUS Multicenter, Phase 2, Randomized Clinical Trial
Susana Banerjee, Gaia Giannone, Andrew R. Clamp, Darren P. Ennis, Rosalind M. Glasspool, Rebecca Herbertson, Jonathan Krell, Ruth Riisnaes, Hasan B. Mirza, Zhao Cheng, Jacqueline McDermott, Clare Green, Rebecca S. Kristeleit, Angela George, Charlie Gourley, Liz-Anne Lewsley, Debbie Rai, Udai Banerji, Samantha Hinsley, Iain A. McNeish
December 2022
Cancer Research
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
Gwo Yaw Ho, Elizabeth L. Kyran, Justin Bedo, Matthew J. Wakefield, Darren P. Ennis, Hasan B. Mirza, Cassandra J. Vandenberg, Elizabeth Lieschke, Andrew Farrell, Anthony Hadla, Ratana Lim, Genevieve Dall, James E. Vince, Ngee Kiat Chua, Olga Kondrashova, Rosanna Upstill-Goddard, Ulla-Maja Bailey, Suzanne Dowson, Patricia Roxburgh, Rosalind M. Glasspool, Gareth Bryson, Andrew V. Biankin; Scottish Genomes Partnership; Susanna L. Cooke, Gayanie Ratnayake, Orla McNally, Nadia Traficante; Australian Ovarian Cancer Study; Anna DeFazio, S. John Weroha, David D. Bowtell, Iain A. McNeish, Anthony T. Papenfuss, Clare L. Scott, Holly E. Barker
October 2022
Gynecologic Oncology
A novel cell line panel reveals non-genetic mediators of platinum resistance and phenotypic diversity in high grade serous ovarian cancer
Joseph I. Hoare, Helen Hockings, Jayeta Saxena, Vera L Silva, M.J. Haughey, Georgina E. Wood, Francesco Nicolini, Hasan B. Mirza, Iain A. McNeish, Weini Huang, Eleni Maniati, Trevor A. Graham, Michelle Lockley
July 2022
Clinical Cancer Research
The genomic landscape of early stage ovarian high grade serous carcinoma
Zhao Cheng, Hasan Mirza, Darren Ennis, Philip Smith, Lena Morrill Gavarró, Chishimba Sokota, Gaia Giannone, Teodora Goranova, Thomas Bradley, Anna Piskorz, Michelle Lockley, Baljeet Kaur, Naveena Singh, Laura Tookman, Jonathan Krell, Jacqueline McDermott, Geoff Macintyre, Florian Markowetz, James Brenton, and Iain McNeish
April 2022
Molecular Cancer Therapeutics
Dual G9A/EZH2 inhibition stimulates anti-tumour immune response in ovarian high grade serous carcinoma
Pavlina Spiliopoulou, Sarah Spear, Hasan Mirza, Ian Garner, Lynn McGarry, Fabio Grundland-Freile, Zhao Cheng, Darren P. Ennis, Nayana Iyer, Sophie McNamara, Marina Natoli, Susan Mason, Karen Blyth, Peter D. Adams, Patricia Roxburgh, Matthew J. Fuchter, Bob Brown, and Iain A. McNeish
January 2019
Molecular Cancer Therapeutics
A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics
December 2018
Cell Reports
Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
October 2018
Clinical Cancer Research
March 2018
Nature Communications
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra & Andrew N. J. Tutt
January 2018
Molecular Cancer Therapeutics
November 2016
The Journal of Pathology
Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer
Gabriele Corda, Gianluca Sala, Rossano Lattanzio, Manuela Iezzi, Michele Sallese, Giorgia Fragassi, Alessia Lamolinara, Hasan Mirza, Daniela Barcaroli, Sibylle Ermler, Elisabete Silva, Hemad Yasaei, Robert F Newbold, Paola Vagnarelli, Marcella Mottolese, Pier Giorgio Natali, Letizia Perracchio, Jelmar Quist, Anita Grigoriadis, Pierfrancesco Marra, Andrew N Tutt, Mauro Piantelli, Stefano Iacobelli, Vincenzo De Laurenzi, Arturo Sala
August 2015
Breast Cancer Research and Treatment
Selection and evolution in the genomic landscape of copy number alterations in ductal carcinoma in situ (DCIS) and its progression to invasive carcinoma of ductal/no special type: a meta-analysis
Swapnil Ulhas Rane, Hasan Mirza, Anita Grigoriadis, Sarah E. Pinder
May 2015
Cancer Discovery
Genomic complexity profiling reveals that HORMAD1 overexpression contributes to homologous recombination deficiency in triplenegative breast cancers
March 2015
Molecular Oncology
Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms
Philip C. Schouten, Anita Grigoriadis, Thomas Kuilman, Hasan Mirza, Johnathan A. Watkins, Saskia A. Cooke, Ewald van Dyk, Tesa M. Severson, Oscar M. Rueda, Marlous Hoogstraat, Caroline V.M. Verhagen, Rachael Natrajan, Suet-Feung Chin, Esther H. Lips, Janneke Kruizinga, Arno Velds, Marja Nieuwland, Ron M. Kerkhoven, Oscar Krijgsman, Conchita Vens, Daniel Peeper, Petra M. Nederlof, Carlos Caldas, Andrew N. Tutt, Lodewyk F. Wessels, Sabine C. Linn
July 2011
BioinformationEvidences of lateral gene transfer between archaea and pathogenic bacteria
Habib Bokhari, Maryam Anwar, Hasan Mirza, Patrick Martin Gillevet
PMID: 21769188
July 2010
Journal of Bioinformatics and Sequence AnalysisIn silico identification of potential horizontal gene transfer events between archaea and pathogenic bacteria
Hasan Mirza, Maryam Anwar, Habib Bokhari